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Guangzhou New Sino Biotech Co., Ltd.
Guangzhou New Sino Biotech Co., Ltd.  

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Honokiol +Magnolol Magnolia Officinalis Bark Extract 

Payment Terms: T/T,L/C 
Place of Origin: Guangdong, China (Mainland) 
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Product Detail

Model No.: NSBI12096
Production Capacity: 1000 kg/m
Delivery Date: 5 days
CAS Number: 528-43-8(Magnolol), 35354-7...
Testing Method: HPLC
Applications: Pharmaceuticals
Means of Transport: By Air By Sea By Courier
Packing: 1 kg/alluminium foil bag; 2...
Botanical Source: Magnolia Officinalis
Part of Plant Used: Magnolia Bark
Specification: 2%, 3%, 5% Magnolol, 10-98%...

Magnolia Bark Extract (Magnolol and Honokiol) is one of Guangzhou New Sino Biotech Companys most competitive products.

Specifications

Magnolia Bark Extract

10-98% Magnolol+Honokiol

10-98% Magnolol

2-99% Honokiol (with natural ratio of Honokiol)


Product Specifications:

10-98% Magnolol+Honokiol HPLC
10-98% Magnolol
2-99% Honokiol (with natural ratio of Honokiol) HPLC


Features and Benefits:

Magnolia Bark Extract (Magnolol and Honokiol) is one of Guangzhou New Sino Biotech Company's most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology from Magnolia officinalis bark.

• High purity: over 95%
• NO solvent - residual free
• Pesticide-free
• Grey-white to Crystal white in appearance
• High anti-bacteria, and longer shelf life


Product Name
Magnolia Bark Extract
   Latin Name
Magnolia officinalis
   Plant part used
Bark
   Active Ingredient
Magnolol &. Honokiol
   Specification
2%, 3%, 5% Magnolol, 10-98% Magnolol+Honokiol
   Test Method
HPLC
   Case No
528-43-8
   Main Function
Anti-tumorigenic and Anti-cancer, Anti-anxiety, Anti-thrombolytic, Reduce allerg

Brief Introduction

Synonyms
--- Hou Po Houpu magnolia, Magnolia obovata (Japanese species), Magnolia grandifloris

Magnolol, Dehydrodichavicol

Chemical Name:
4-Allyl-2-(5-allyl-2-hydroxy-phenyl)phenol; 5,5'-Diallyl-2,2'-biphenyldiol 5,5'-Diallyl-2,2'-dihydroxybiphenyl

CAS No.: 528-43-8

Molecular Formula: C18H18O2

Mol. Wt.: 266.334

Molecular Structure:




Honokiol, Houpa, HNK


Chemical Name: 2-(4-hydroxy-3-prop-2-enyl-phenyl)- 4-prop-2-enyl-phenol

CAS No.: 35354-74-6

Molecular Formula: C18H18O2

Mol. Wt.: 266.334

Molecular Structure:




Magnolia is a large genus of about 210 flowering plant species in the subclass Magnolioideae of the family Magnoliaceae.

Magnolia is an ancient genus. Having evolved before bees appeared, the flowers developed to encourage pollination by beetles. As a result, the carpels of Magnolia flowers are tough, to avoid damage by eating and crawling beetles. Another primitive aspect of Magnolias is their lack of distinct sepals or petals.



Magnolol
is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis). It is known to act on the GABAA receptors in rats, as well as having antifungal properties.

The Magnolia Bark Extract (Magnolol and Honokiol) used in dietary supplements and for medicine uses is derived from the bark of the plant Magnolia officinalis.


Benefits

•Anti-anxiety
• Potent and Highly Tolerable Anti-tumorigenic Effects (Honokiol)
•Anti-depression and Anxiolytic Effects (Honokiol)
• Act on the GABAA receptors (Magnolol)
• Neurotrophic (Honokiol)
• Antifungal, Anti-bacerial (Inhibit bacteria responsible for caries and periodontal disease) (Magnolol and Honokiol)
• Anti-thrombotic Effects (Honokiol)
•Reduce allergic and asthmatic reactions (Magnolol and Honokiol)
• Anti-emetic Effects (Honokiol)

Mechanism

Anti-tumorigenic activities: Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, and colon cancer cell lines. Honokiol inhibits phosphorylation of Akt, p44/42 mitogen-activated protein kinase (MAPK), and src. Additionally, honokiol modulates the nuclear factor kappa B (NF-κB) activation pathway, an upstream effector of vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2), and MCL1, all significant pro-angiogenic and survival factors. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides. So potent is honokiol's pro-apoptotic effects that it overcomes even notoriously drug resistant neoplasms such as multiple myeloma and chronic B-cell leukemia.

Neurotrophic activity: Honokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons. Additionally, honokiol increases free cytoplasmic Ca2+ in rat cortical neurons.

Anti-thrombolytic activity: Honokiol inhibits platelet aggregation in rabbits in a dose-dependent manner, and protects cultured RAEC against oxidized low density lipoprotein injury. Honokiol significantly increases the prostacyclin metabolite 6-keto-PGF1alpha, potentially the key factor in honokiol's anti-thrombotic activity.

Safety

Magnolia Bark Extract (Magnolol and Honokiol) is safe.

Dosage

• Consult physicians for different condition specifics.
Part used: Bark                  


Mr. Michael Lee
 Mr. Michael Lee
Export Manager
Tel: 86-20-36313687
Fax: 86-20-62824829
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Company Info

Guangzhou New Sino Biotech Co., Ltd. [China (Mainland)]


Business Type:Manufacturer, Trading Company
City: Guangzhou
Province/State: Guangdong
Country/Region: China (Mainland)

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